Which classification of drugs has the lowest potential for abuse?

Schedule V drugs are classified as having the lowest potential for abuse compared to other schedules. This classification often includes substances that contain limited amounts of certain narcotics, which can be used for medicinal purposes, such as cough preparations that contain less than 200 milligrams of codeine per 100 milliliters or per 100 grams. The lower potential for abuse is due to the fact that these drugs are generally considered to have a valid medical application and are less likely to lead to physical or psychological dependence.

In contrast, Schedule I substances have no accepted medical use and a high potential for abuse, making them the most restricted. Schedules II and III drugs also have a higher potential for abuse compared to Schedule V, with Schedule II drugs having a high potential for severe psychological or physical dependence. Thus, when considering the classifications of controlled substances and their associated potential for abuse, Schedule V stands out as the category least likely to result in misuse or addiction.